Photo credit: DiasporaEngager (


NHIS data indicate that many adults in the United States remained unprotected against vaccine-preventable diseases in 2018. Adult vaccination coverage remained similar to that in 2017 for most vaccines, with modest increases observed only for hepatitis B vaccination and HPV vaccination (males aged 19–26 years and Hispanic females aged 19–26 years). Having health insurance coverage, having a usual place for health care, and having ≥1 physician contact during the preceding year were associated with higher vaccination coverage. Vaccination coverage estimates for three of the four vaccines in this report that are included in Healthy People 2020 (influenza, pneumococcal, and hepatitis B [for HCP] vaccines) were below the respective target levels, even among insured adults and adults with multiple health care visits during the preceding year (10). Herpes zoster vaccination coverage in 2018 was 4.5 percentage points above the Healthy People 2020 target of 30% (10). Racial and ethnic differences in vaccination coverage persisted for all vaccinations with lower coverage generally for most vaccinations among non-White and Hispanics compared with non-Hispanic White adults. Depending on the vaccine, 20.1%–87.5% reported not having received vaccinations among adults who had health insurance and ≥10 physician contacts during the preceding year, indicating multiple missed opportunities for vaccination and the need to increase routine assessment of adult vaccination needs and vaccination with recommended vaccines.

Composite Adult Vaccination Quality Measure

Coverage for the age-appropriate composite measures was low in all age groups. The composite adult vaccination quality measure presented in this report was adopted by the Indian Health Service and added to the Healthcare Effectiveness Data and Information Set (HEDIS) by the National Committee for Quality Assurance (NCQA) for first-year reporting beginning in 2018 (18). HEDIS is a set of national performance measures used to compare health plans and drive improvement in important facets of health care delivery. NCQA added the Adult Immunization Status measure to the HEDIS Health Plan Set to assess routine vaccination for select vaccines. The measure includes four rates assessing receipt of influenza, Td/Tdap, herpes zoster, and pneumococcal vaccination for adults aged ≥19 years and a composite rate to provide a summary of performance across these different vaccines. The composite rate assessed the total number of vaccines that were received across a health plan’s member population per clinical guidelines (i.e., the sum of the individual vaccines administered divided by the sum of the individual vaccines required). The measure was specified for the HEDIS Electronic Clinical Data Systems reporting method. Data sources included administrative claims, electronic medical records, registries, case management systems, and health information exchanges.

The vaccination coverage estimates for the composite adult vaccination quality measure presented in this report derived from self-report of vaccination status will differ from those generated by the NCQA, which are based on vaccination records from electronic clinical data systems for members enrolled in participating health plans. In addition, CDC and NCQA use different approaches for calculating coverage estimates. The CDC analytic approach uses persons as the unit of analysis, where estimates for each age group represent the proportion of adults who reported receipt of all the vaccines routinely recommended for that age group. The composite numerator for CDC estimates includes only those persons who reported receiving all the recommended vaccines (a unit of person); the composite denominator for estimates includes all the persons with indications for vaccination on the basis of the recommended vaccines for that specific age group (a unit of person, each person counted once) (Supplementary Table, The NCQA analytic approach (19) uses recommended vaccines as the unit of analysis; specifically, the number of vaccinations administered or contraindicated (numerator) out of the possible number of vaccinations needed by plan members according to ACIP recommendations for the age group (denominator) (i.e., the percentage of the total recommended number of vaccinations, per the guidelines for that age, that were administered as indicated [i.e., the sum of the individual vaccines administered divided by the sum of the individual vaccines required]). Also, in contrast to the CDC approach, NCQA uses actual vaccination data from the participating health plans (commercial, Medicare, and Medicaid) to generate estimates, different exclusion criteria for analyses than CDC, different measurement periods for ascertaining influenza and Td/Tdap vaccination status, and different criteria for herpes zoster vaccination (e.g., the criteria are vaccine-type specific with the recombinant zoster vaccine criterium requiring series completion to be counted). In addition, the NCQA criterion for pneumococcal vaccination of plan members aged ≥66 years at the start of the measurement period was based on the previous “series completion” ACIP recommendations in effect during 2018 (i.e., receipt of both PCV13 and PPSV23 in series with the recommended interval based on whether the recipient was pneumococcal vaccine-naïve or had previously received PPSV23) (Supplementary Table, (20). For the comparison estimates in this report, recommended vaccines were adapted as the unit of analysis. The composite numerator of the adapted NCQA approach indicates whether the vaccination was administered (a unit of recommended vaccinations received). The composite denominator indicates the number of recommended vaccinations for persons based on their age (a unit of recommended vaccinations). For the adapted NCQA approach, influenza vaccination was measured as receipt during the preceding 12 months, Tdap was measured as receipt during the preceding 10 years, and herpes zoster vaccines and pneumococcal vaccine were measured as having ever received these vaccinations. For actual NCQA estimates: 1) influenza vaccination was measured as receipt on or between July 1 of the year before the measurement period and June 30 of the measurement period; 2) Td/Tdap vaccination was measured as receipt of at least one Td or Tdap vaccine between 9 years before the start of the measurement period and the end of the measurement period; 3) persons received at least 1 dose of the herpes zoster live vaccine or 2 doses of the herpes zoster recombinant vaccine (at least 28 days apart) anytime on or after the person’s 50th birthday; and 4) persons were administered both the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccharide vaccine at least 12 months apart, with the first occurrence after the age of 60 years.

NCQA revisited the usefulness of the composite rate during a re-evaluation of the measure in 2020. Stakeholder feedback included concerns about the usability of the composite rate as constructed, particularly with combining vaccines recommended for younger versus older adults into a composite. Thus, NCQA removed the composite rate from the Adult Immunization Status measure in 2020. The four individual vaccine rates for influenza, Td/Tdap, herpes zoster, and pneumococcal vaccination will continue to be reported.

Composite performance measures, which combine multiple individual (“component”) quality measures, provide a useful way to examine overall health system performance in implementing standards of care as well as a reminder and an incentive for implementing these standards by providers (11). The U.S. Department of Health and Human Services has proposed a developmental Healthy People 2030 (HP2030) composite adult vaccination quality measure as a new objective to assess overall adult vaccination performance (21). This developmental measure targets increasing the proportion of adults age ≥19 years who receive recommended age-appropriate vaccines. This objective is a high-priority public health issue with evidence-based interventions; however, reliable baseline data are required before it can become a core HP2030 objective. The composite adult vaccination quality measure estimates in this report indicate that, despite variable coverage with individual recommended vaccines, few adults in any age group were fully vaccinated according to ACIP recommendations. Presenting both composite and component measures allows assessment of overall performance and targeted interventions for improvement.

Influenza Vaccination

Since the 2010–11 influenza season, ACIP has recommended annual influenza vaccination for all persons aged ≥6 months (22). By the 2017–18 season (seven seasons after annual influenza vaccination was recommended for all adults), vaccination coverage among adults aged ≥19 years was 46.1%, with an average annual 1.1 percentage point increase from the 2009–10 through the 2017–18 seasons. However, by the 2017–18 season, approximately 50% of adults had not received influenza vaccine, and coverage was well below the Healthy People 2020 target of 70% (10). In addition, coverage among adults aged ≥19 years with high-risk conditions remained low (61.0% in the 2017–18 season). Even after its universal influenza vaccination recommendation, ACIP continued to emphasize that persons with high-risk conditions should be a focus of vaccination efforts (22). Persons with underlying health conditions might not consider themselves as high risk, limiting the effectiveness of targeted messages. Many persons with high-risk conditions see subspecialists, who are less likely to recommend influenza vaccination than general practitioners (23).

Vaccination of HCP is an important component of influenza prevention programs in the United States (24). Vaccination of HCP could reduce transmission of influenza in health care settings, staff illness and absenteeism, and influenza-related morbidity and mortality (24). Despite the availability of safe and effective influenza vaccines (25,26), influenza vaccination coverage among HCP remains suboptimal (4,15,2730). By the 2017–18 season, vaccination coverage among HCP overall (71.8%) and among HCP with and without direct patient care (72.6% and 70.5%, respectively) remained far below the Healthy People 2020 target for HCP of 90% (10).

Previous studies of influenza illnesses and hospitalizations that could be averted by vaccination have indicated that higher vaccination rates could prevent a substantial number of influenza cases and hospitalizations (31). For example, one study indicated that a 5% influenza vaccination coverage increase would result in 785,000 fewer illnesses (56% among those aged 18–64 years) and 11,000 fewer hospitalizations (31). More effort is needed to reach the Healthy People 2020 and 2030 targets to benefit fully from influenza vaccination (10,32). Ensuring that all persons who visit a health care provider during the influenza season receive a vaccination recommendation and offer from their provider and use of immunization information systems could increase influenza vaccination rates (33,34). Employers and health care administrators also should implement evidence-based interventions to increase influenza vaccination coverage among HCP, including on-site vaccination at no or low cost to HCP (30).

Pneumococcal Vaccination

The overall pneumococcal vaccination estimates in this report include respondents who received PCV13, PPSV23, or both. Respondents indicating receipt of ≥2 doses of pneumococcal vaccine include adults who are recommended to receive 1 dose of PPSV23 only, or a dose of PCV13 and up to 2 doses of PPSV23 (17,35). Since 1997, ACIP has recommended PPSV23 vaccination of all adults aged ≥65 years and younger adults with chronic or immunocompromising medical conditions (35). In 2012, ACIP recommended PCV13 to adults aged 19–64 years at increased risk and, in 2014, ACIP recommended routine use of PCV13 in series with PPSV23 for all adults aged ≥65 years (17,36). At that time, ACIP recognized that there would be a need to reevaluate this recommendation because it was anticipated that PCV13 use in children would continue to reduce disease burden among adults through reduced carriage and transmission of vaccine serotypes from vaccinated children (i.e., PCV13 indirect effects). On June 26, 2019, after having reviewed the evidence accrued during the preceding 3 years (37), ACIP voted to remove the recommendation for routine PCV13 use among adults aged ≥65 years and to recommend administration of PCV13 based on shared clinical decision-making for adults aged ≥65 years who do not have an immunocompromising condition, cerebrospinal fluid leak, or cochlear implant, and who have not previously received PCV13. All adults aged ≥65 years should continue to receive 1 dose of PPSV23 (36). Recommendations and guidance and implementation considerations for recommendations on shared clinical decision-making are available (37,38).

Pneumococcal vaccination of persons aged 19–64 years at increased risk increased during 2010–2018 but remains well below the Healthy People 2020 target of 60% (10). Millions of adults in the United States have conditions placing them at increased risk for complications of pneumococcal disease or other vaccine-preventable infections (39,40). Adults with certain chronic and immunocompromising health conditions are at substantially increased risk for IPD compared with adults without these conditions, with disease rates up to 33 times higher in some immunocompromised adults (41). In this report, only one fourth of adults aged 19–64 years at increased risk reported ever receiving a dose of pneumococcal vaccine, leaving approximately 70% of adults at increased risk unprotected. Pneumococcal vaccination of adults aged ≥65 years increased during 2010–2018; however, coverage remains well below the Healthy People 2020 target of 90% (10). Achieving higher pneumococcal vaccination levels can reduce morbidity and mortality related to pneumococcal disease.

Herpes Zoster Vaccination

Overall, in 2018, herpes zoster vaccination coverage among adults aged 50–59 years was 5.8%, similar to the estimate for 2017. ZVL was licensed by the U.S. Food and Drug Administration (FDA) for adults aged ≥50 years, but not recommended by ACIP for adults aged 50–59 years. The ACIP recommendation was driven by concerns about waning immunity of ZVL in vaccine recipients aged 50–59 years combined with increasing risk for herpes zoster with age and cost-effectiveness analyses (42). In October 2017, ACIP recommended the recent FDA-approved RZV for use in immunocompetent adults aged ≥50 years, revaccination of those who previously received ZVL, and preferential use of RZV over ZVL because of its higher and more long-lasting efficacy (43). The differences between FDA’s ZVL licensing and ACIP recommendations for ZVL use likely influenced the usage patterns of ZVL before widespread distribution of RZV. The limited use of ZVL in persons aged 50–59 years likely reflects use of an FDA-approved vaccine among some vaccination providers and individual clinical decision-making with their patients, illustrating the strong influence of ACIP recommendations on national vaccination practices.

ZVL coverage among adults aged ≥60 years was 34.9% in 2017 (9) and 28% among the same age group in 2018. Even if no ZVL had been administered in 2018, that might be insufficient to explain the decreased coverage compared with 2017. This observed decrease in coverage might reflect the effect of the change in herpes zoster vaccination recommendations in October 2017 and the questions asked in the 2018 NHIS to ascertain type of herpes zoster vaccine received. In 2017, respondents were asked if they had ever received a shingles vaccine. The 2018 NHIS included questions to ascertain herpes zoster vaccination by type of vaccine (ZVL versus RZV), number of vaccine doses received, and timing of vaccine receipt (13).

Results from this study indicated that recently recommended RZV coverage (≥1 dose) was 2.4% among adults aged ≥50 years. ACIP recommended 2 doses of RZV to adults aged ≥50 years (43). This study showed that in 2018, RZV coverage (≥2 dose) was 0.6% among adults aged ≥50 years. More RZV doses were distributed in the third and fourth quarters (64%) in 2018 compared with the first two quarters (36%) (CDC unpublished data, 2018), and uneven distribution of this new vaccine could have had an impact on vaccine receipt, estimation of vaccination coverage, and series completion. The results from this study provides first-year RZV coverage following the 2017 ACIP recommendation and a baseline for assessing changes in herpes zoster vaccination coverage following introduction of RZV. Monitoring RZV vaccine use is important for developing strategies to improve coverage for this newly recommended vaccine.

Overall, herpes zoster vaccination coverage for adults aged ≥60 years was 34.5% in 2018, similar to the 2017 estimate and 4.5 percentage points above the Healthy People 2020 target of 30% (10). Although the Healthy People 2020 target was achieved, approximately 65% of adults recommended to receive this vaccine remain unprotected. Barriers that might have constrained overall herpes zoster vaccination uptake include shortages of herpes zoster vaccines (e.g., there was a ZVL shortage in 2011 and a RZV shortage in 2018) as well as financial and logistic challenges (44,45). The high cost for providers to purchase a supply and high out-of-pocket costs for patients are well-documented barriers (46,47). For ZVL, challenges existed to stocking the vaccine (which requires freezer storage), and for ZVL and RZV, variation in out-of-pocket payments for some Medicare Part D beneficiaries existed depending on their specific plan (46,47). RZV must be stored in a refrigerator (but should not be frozen) and administered immediately after reconstitution or stored in a refrigerator and used within 6 hours. Studies showed that provider recommendation was a strong predictor for vaccination (48,49). Health care providers should routinely assess patients’ vaccination status and strongly recommend needed vaccines to adults (48,49).

Tetanus Toxoid–Containing Vaccination

ACIP updated the adult Tdap vaccination recommendation to include all adults aged ≥19 years who have not yet received a dose of Tdap, including those aged ≥65 years, in 2012 (50). Tdap should be administered regardless of interval since the last Td shot. A single dose of Tdap is particularly important for adults who have or who anticipate having close contact with an infant aged <1 year (e.g., parents, grandparents, childcare providers, and HCP) to reduce risk for transmitting pertussis to infants too young to be vaccinated, who are at the greatest risk for severe pertussis including hospitalization and death. Overall, Tdap coverage has remained low for all age groups and among adults living with an infant aged <1 year. In 2018, although there was no increase compared with the 2017 estimate, the trend test found that Tdap coverage increased significantly from 2010 to 2018. Health care providers should not miss an opportunity to vaccinate adults aged ≥19 years who have not received Tdap previously.

Vaccination also offers the best protection against pertussis infection in HCP (5153). In 2006, ACIP recommended that HCP aged 19–64 years receive a single dose of Tdap to reduce the risk for transmission of pertussis in health care settings (52). In 2010, ACIP updated HCP recommendations indicating that all HCP, regardless of age, should receive a single dose of Tdap as soon as feasible if they had not previously received Tdap (24). Vaccinating HCP with Tdap can be a cost-effective strategy to prevent outbreaks in health care settings (5153). However, as of 2018, Tdap vaccination coverage among HCP is suboptimal (55.8%).

Tdap vaccination coverage among HCP was lower compared with influenza and hepatitis B vaccination coverage among HCP. Influenza and hepatitis B vaccines are two other vaccines recommended for HCP in the United States (24,54). Influenza (2017–18 season) and hepatitis B (2018) vaccination coverage among HCP was 71.8% and 67.2%, respectively. Coverage among HCP with direct patient care was 72.6% and 75.3%, respectively. However, influenza and hepatitis B vaccination have been recommended for HCP since 1984 and 1982, respectively, compared with Tdap, which has been recommended for HCP only since 2006 (52,54,55). Other factors, such as perceived risk, employer requirements, and targeted vaccination campaigns, also might contribute to higher influenza and hepatitis B vaccination among HCP (5457). Since Tdap vaccination coverage was first assessed in the United States in 2008 (52), Tdap coverage among HCP has increased from 15.9% in 2008 (58) to 55.8% in 2018. Continued monitoring of Tdap vaccination among HCP is useful for evaluating vaccination campaigns and planning and to control pertussis among HCP and their contacts.

Hepatitis A Vaccination

Hepatitis A is an acute infection that can result in mild illness or be severe enough to result in hospitalization or, rarely, in death. Incidence rates decreased by approximately 95% from 1995 to 2011, then increased by 140% from 2011 to 2017 (59). Incidence rates in the United States have been influenced by occasional outbreaks, often linked to imported food, and among nonimmune persons experiencing homelessness (60). Although the average number of annual hepatitis A virus (HAV) infections reported to CDC in recent years has declined substantially compared with 2000, fluctuations have occurred during the preceding 20 years because of large outbreaks. After a long downward trend, the first increase between 2012 and 2013 (1,562 and 1,781 reported cases, respectively) was because of a large multistate outbreak associated with pomegranate arils imported from Turkey (61). From 2015 to 2016, reported cases again increased by 44.4% from 1,390 to 2,007 cases. The 2016 increase was caused by two hepatitis A outbreaks, each of which was linked to imported foods. Increases might be expected because of ongoing outbreaks reported to CDC among persons who use drugs, persons experiencing homelessness (62), and men who have sex with men (63). Men who have sex with men should be vaccinated against hepatitis A and hepatitis B and tested for hepatitis B. Optimal use of vaccination can substantially reduce the hepatitis A disease burden (64). One study found that among U.S.-born adults aged ≥20 years, HAV susceptibility prevalence (total antibody to HAV negative) was 74.1% during 2007–2016, indicating that HAV immunity levels among adults was low (65). In 1995, the first hepatitis A vaccine became available in the United States. ACIP recommended hepatitis A vaccination of international travelers, men who have sex with men, persons who use injection and noninjection drugs (i.e., all those who use illegal drugs), persons who have occupational risk for exposure, persons who anticipate close personal contact with an international adoptee, persons experiencing homelessness, persons infected with HIV, persons with chronic liver disease, persons living in group settings for those with developmental disabilities, persons who are incarcerated, pregnant women who are identified to be at risk for HAV infection during pregnancy, and adults aged >40 years (66).

Information on hepatitis A vaccination was available for the adult general population and selected populations for whom hepatitis A vaccination specifically is indicated (only for those with foreign travel to areas of high or intermediate endemicity and those with chronic liver disease). Although hepatitis A vaccination of adult travelers was higher during 20102018 than among adult nontravelers, overall hepatitis A vaccination among travelers aged ≥19 years and adults aged ≥19 years with chronic liver disease has remained low (as of 2018, 18.9% and 15.8%, respectively). HCP are encouraged to assess the needs of their patients for hepatitis A vaccine and offer it when appropriate. To further improve hepatitis A vaccination coverage and reduce the burden of hepatitis A infection in the United States, HCP are encouraged to adopt strategies to identify candidates for hepatitis A vaccination (e.g., implementing standing orders in electronic medical records, collocating vaccination at homeless shelters and syringe service programs, and offering vaccine to residents and staff of long-term care centers), and to ensure that traveling adults and all adults at increased risk for hepatitis A infection or seeking protection from hepatitis A infection are offered hepatitis A vaccine (33,34,64,6668). Travelers, especially healthy travelers with no physician visit, should see their doctor to discuss their travel-related vaccinations and other preventive care services. CDC recommends that international travelers should schedule a visit to a primary doctor or a travel medicine provider 4–6 weeks before their trip (6769).

Hepatitis B Vaccination

ACIP has recommended a 3-dose hepatitis B vaccine series since 1982 for HCP (70,71), since 1991 for travelers to or persons working in countries with high or intermediate hepatitis B endemicity (72), and since 2011 for unvaccinated adults with diabetes aged 19–59 years. In addition, vaccine can be administered to unvaccinated adults with diabetes aged ≥60 years at the discretion of their HCP (73,74). Despite these longstanding recommendations for hepatitis B vaccination, coverage remained low in 2018. Furthermore, overall hepatitis B vaccination among travelers and adults with chronic liver disease has remained low, although hepatitis B vaccination among travelers was higher in 2018 and preceding years than among nontravelers.

Several factors might contribute to low hepatitis B vaccination among travelers to countries where hepatitis B virus is endemic. Many travelers to international destinations might omit seeking travel health advice because of lack of awareness of the risk for travel-associated infection and travel-related vaccination recommendations (7577). Some travelers (e.g., business travelers, journalists, and relief workers) might be notified of travel on short notice and have little time for vaccination before departure, even though these travelers should be vaccinated in expectation of travel to hepatitis B virus–endemic areas to protect themselves (7577). Travelers might believe that travel of short duration, to resorts or on tours, will pose little risk for travel-related diseases (7881). HCP are encouraged to adopt strategies to identify candidates for hepatitis B vaccination and to ensure that traveling adults, all adults at increased risk for hepatitis B infection, or those seeking protection from hepatitis B infection are offered hepatitis B vaccine (7581). Travelers to a country of high or intermediate hepatitis B endemicity are encouraged to schedule a visit with their doctor or a travel medicine provider 4–6 weeks before travel to discuss the need for travel-related vaccinations (7577).

In addition, during 2010–2018, estimates of hepatitis B vaccination among HCP did not improve, ranging from 61% to 67%, well below the Healthy People 2020 target of 90% (10). Hepatitis B vaccination coverage among HCP with direct patient care was higher (75%), although still below the Healthy People 2020 target (10). Before hepatitis B vaccination was widely implemented, hepatitis B virus (HBV) infection was recognized as a common occupational risk among HCP (82,83). Routine hepatitis B vaccination of HCP and the use of standard precautions have resulted in a 98% decline in HBV infections among HCP from 1983 through 2010 (84). The Occupational Safety and Health Administration mandates that employers offer hepatitis B vaccination to all personnel who have occupational risk and that postexposure prophylaxis be available following an exposure (74,84,85). Continued efforts are needed to increase hepatitis B vaccination coverage among unvaccinated HCP to protect workers and patients (86).

HPV Vaccination

HPV is the most common sexually transmitted infection in men and women in the United States (8791). Vaccination can prevent HPV infection and associated diseases including genital warts, precancerous lesions, anogenital cancers, and oropharynx cancer (87). In 2006, quadrivalent HPV vaccine was recommended by ACIP for use in females aged 11 or 12 years and for those aged 13–26 years who had not been vaccinated previously or who had not completed the 3-dose series (87). In 2009, ACIP provided guidance that the quadrivalent vaccine could be given to males aged 9–26 years (a permissive recommendation) (92,93). In 2011, ACIP recommended routine use of HPV vaccine among males aged 11 or 12 years and for those aged 13–21 years who had not been vaccinated previously or who had not completed the 3-dose series and a permissive recommendation for males aged 22–26 years (91,94). In 2015, after 9-valent HPV vaccine was licensed, ACIP recommended any of the three licensed HPV vaccines (quadrivalent, bivalent, or 9-valent) for females and quadrivalent or 9-valent vaccine for males among the same age groups previously recommended (95). In 2016, ACIP recommended a 2-dose schedule for HPV vaccination of females and males initiating their vaccination before age 15 years (96). In 2019, ACIP updated recommendations on HPV catch-up vaccination for U.S. adults to include all persons through age 26 years (97). For adults aged 27–45 years, shared clinical decision-making about HPV vaccination is recommended because certain persons who are not adequately vaccinated might benefit (97).

Although receipt of at least 1 dose of HPV vaccine increased from 20.7% in 2010 to 52.8% in 2018 for females aged 19–26 years, and from 2.1% in 2011 to 26.3% in 2018 among males aged 19–26 years, as of 2018, coverage has remained low, and many young adult females (47.2%) and males (73.7%) remain unvaccinated and vulnerable to cancers that safe, effective HPV vaccines can prevent. Findings on age at first dose of HPV vaccination of adults indicated that most female and male respondents in the 2018 NHIS reported receiving the first dose of HPV vaccine at age ≥13 years. In 2018, approximately 12% of females and 15% of males aged 19–26 years not vaccinated at age ≤18 years reported receiving the first dose of HPV vaccine as a catch-up dose at age 19–26 years. Since HPV vaccine licensure, multiple cohorts of unvaccinated adolescents and young adults have accumulated. For example, in the 2018 National Immunization Survey–Teen (98), provider-reported vaccination histories indicated that 23.7% of females and 35.5% of males aged 17 years were unvaccinated (having not received at least one HPV vaccine dose) (98). These estimates reflect the current pool of females and males who could benefit from catch-up vaccination and the number of unprotected older adolescents adding to that pool annually, indicating the importance of catch-up vaccination among young adults.

HCP recommendations for vaccination are strongly associated with a patient’s receipt of vaccines (34,99103). Findings from one report indicate that among male adolescents with a HCP recommendation, HPV coverage was approximately two times higher than that among those without a provider recommendation (68.8% versus 35.4%) (48). The same report found that provider recommendation was associated with higher HPV vaccination coverage in most states (48). Another study found that HPV vaccination coverage among female adolescents (≥1 dose) was 58.3% among those with a provider recommendation compared with only 20.7% among those without a provider recommendation (104). Other research has indicated that recommendations from providers increase parental acceptance of vaccination of their children and that parents change their minds about delaying and refusing vaccines because of information or assurances from HCP (105,106). HCP conversations with parents can be an important pathway to achieving higher HPV vaccination coverage of female adolescents, including talking to parents about the HPV vaccine, giving parents time to discuss the vaccine, and making a strong recommendation for HPV vaccination (107). However, in 2016, up to 35% of parents of adolescents reported not receiving a provider recommendation for the vaccine (48). Increasing HPV vaccination could lead to greater decreases in HPV-attributable diseases in the United States. Continued efforts are needed to improve coverage among members of the primary target group for HPV vaccine (girls and boys aged 11–12 years) and among all racial and ethnic groups. As more adolescents are vaccinated at the target age group and age into the adult population monitored in NHIS, vaccine coverage estimates are expected to increase. To reduce the amount of time needed to achieve population-level impacts of vaccination, such as reduction in HPV-associated cancer incidence, efforts are also needed to improve catch-up vaccination through age 26 years among those who have not started or completed their vaccination (4,97). Providers should assess vaccination status at clinical encounters, educate persons about the diseases that can be prevented by vaccines, and strongly recommend indicated vaccines (34,99,108).

Trends in Adult Vaccination Coverage

Although the point estimates for each year varied by only a few percentage points, linear trend tests indicated that during 2010–2018, vaccination coverage increased for influenza (among adults aged ≥19 years overall and those with high-risk conditions), pneumococcal (among those aged 19–64 years at increased risk and adults aged ≥65 years), herpes zoster (among adults aged ≥60 years), Tdap (among adults aged ≥19 years), hepatitis A (among adults aged ≥19 years and travelers or nontravelers aged ≥19 years), hepatitis B (among adults aged ≥19 years), and HPV (among women aged 19–26 years) vaccines, and during 2011–2018 for HPV vaccine (among men aged 19–26 years). Although these increases were small, collectively they might have resulted in meaningful reductions in disease among adults (31). Hepatitis B vaccination coverage plateaued among adults aged ≥19 years with chronic liver conditions and travelers or nontravelers aged ≥19 years.

Racial and Ethnic Differences in Vaccination

In 2018, racial/ethnic differences in vaccination coverage persisted for all seven vaccines assessed in this report. Generally, higher coverage was observed for White adults compared with most other groups. Black, Hispanic, and Asian adults had lower vaccination coverage than Whites for all vaccines routinely recommended for adults, with a few exceptions. Among HCP, there were differences for influenza, Tdap, and hepatitis B vaccination, with White HCP generally having higher vaccination coverage compared with Black and Hispanic HCP.

The findings provided in this report are consistent with previous studies (4,109). Although studies indicate that racial and ethnic disparities in childhood vaccination have been reduced substantially or not observed for certain vaccinations (98,110,111), racial and ethnic disparities in adult vaccination persist (4,28,29,111118). School entry vaccination requirements and the Vaccines for Children program, which provides vaccines to children who might otherwise be unable to afford them, might contribute to reduced racial and ethnic disparities in vaccination coverage for children (119121). Multiple factors contribute to racial and ethnic differences in adult vaccination, including differences in attitudes toward vaccination and preventive care, propensity to seek and accept vaccination, variations in the likelihood that providers recommend vaccination, differences in quality of care received by racial and ethnic populations, and differences in concerns about vaccination including vaccine safety (111118). In addition, non-Hispanic Black and Hispanic adults are more likely to be uninsured (122). Lack of medical insurance has been an important predictor of low adult vaccination uptake (4,117,123). Another factor that might contribute to coverage disparities is differential awareness of vaccines. Studies have shown that awareness of Tdap, herpes zoster, and HPV vaccines was significantly lower among racial and ethnic minorities compared with non-Hispanic Whites (57,102,123,124). Older Black adults report more negative attitudes toward influenza vaccination than White adults (113); however, studies of standardized offering of influenza and pneumococcal vaccines have demonstrated reductions in racial and ethnic coverage disparities (125,126). Using a combination of patient tracking, vaccination reminders for providers and patients, and patient outreach and assistance also reduces racial/ethnic vaccination differences (103). Incorporating standards for adult vaccination practices, which include routinely assessing vaccination needs during all clinical encounters, providing a strong recommendation for vaccination to patients with indications, and then offering vaccination at the visit (34) or referring patients for vaccination elsewhere, can reduce vaccination disparities.

Access-to-Care Characteristics and Adult Vaccination Coverage

Consistent with a previous report (127), in this study having health insurance was generally associated with a greater likelihood of having received recommended vaccinations, even after controlling for demographic and access-to-care variables. For many of the vaccines, coverage was greater among adults with private health insurance compared with those reporting public health insurance, but this finding was not consistent for all vaccines and age groups. The factors contributing to vaccination levels by type of health insurance are not well understood. Health insurance coverage, although beneficial in improving access to health care services, might not be sufficient in itself to achieve optimal adult vaccination. In this report, even among adults who had health insurance and ≥10 physician contacts during the preceding year, up to 87.5% reported not receiving one or more recommended vaccines. Provider attitudes toward adult vaccination, practice patterns that do not routinely incorporate assessments for vaccines for adults, and other barriers to vaccination might determine whether patients are offered and receive vaccines (127133).

Generally, persons with a usual place for health care were more likely to report having received recommended vaccinations than those who did not have a usual place for health care, regardless of whether they had health insurance, and vaccination coverage generally increased as the number of physician contacts increased. Having a usual place for health care and routine physician contact can provide important opportunities for providers to educate their patients about vaccine-preventable diseases and to recommend and offer vaccination (102,109,117,134). However, a recent study showed that overall, among adults with a doctor visit, only 57.0% received a provider recommendation for influenza vaccination (49). Patients usually trust the opinions of HCP regarding vaccination more so than opinions from others (34,135). However, only 32% of family physicians and 29% of internists assess their adult patients’ vaccination status at every visit (135).

Adult Vaccination Coverage by Nativity, Years Living in the United States, and Citizenship

Results from this study indicated that adult vaccination coverage was generally lower among foreign-born compared with U.S.-born persons. Vaccination coverage for foreign-born persons differed by time lived in the United States. A previous study showed that vaccination was also associated with language used for interview, race/ethnicity, and birth country/region (136). Among foreign-born persons, vaccination coverage was generally lower among those who were not U.S. citizens, those interviewed in a language other than English, and non-Hispanic Blacks or Hispanics. Hispanic foreign-born adults had the lowest coverage for several vaccines. This finding is particularly relevant because foreign-born persons from Latin America account for more than half of all foreign-born adults in the United States (137139). Vaccination coverage and immunization schedules are different in many countries compared with the United States and vary by country and even by regions within countries (136,140,141). Although immigrant visa applicants and refugees destined for permanent resettlement in the United States are subject to ACIP-recommended vaccination requirements, the differences between the United States and other countries in the schedules of routine vaccinations among adults might contribute to differences in the coverage levels of the vaccines studied. Public policymakers, vaccination programs, and HCP should consider foreign-born populations in their public health assessment, evaluation, and outreach programs that target disadvantaged groups (142).

Improving Adult Vaccination Coverage

Studies indicate that a strong HCP recommendation is closely associated with patient vaccination (48,49,128). Standards for Adult Immunization (the Standards) was published for implementing ACIP recommendations and outlining approaches for improving adult vaccination coverage (33,34). Wider adoption of the Standards (i.e., assessing vaccination status at each adult patient visit, issuing strong recommendations for indicated vaccines, offering vaccines or referring patients to other providers for vaccination, and recording vaccinations received in the Immunization Information System [IIS]) (33,34) will help improve vaccine coverage. Research suggests medical specialists are less likely than primary care clinicians to assess for, recommend, stock, or refer patients for needed vaccines (143). Because patients with conditions placing them at increased risk for infection are likely to receive care from specialists, these encounters might represent missed opportunities for vaccination and could be addressed by consistent implementation of the Standards by these providers. Among the challenges clinicians face in assessing the need for vaccination is availability of a complete and accurate vaccination history along with access at the point of care to the most current vaccination recommendations. Enhancing provider access to IIS could help improve vaccination coverage because IIS can provide consolidated immunization histories for use by a vaccination provider in determining appropriate client vaccinations (144). Nationwide adoption of electronic health records, many of which have the capacity for patient-centered clinical decision support, also offer opportunities for improving adult vaccination coverage (4).

Standardized offering of vaccines reduces but does not eliminate racial/ethnic differences in coverage (15). Although programmatic initiatives designed to improve adult vaccine coverage overall might have a positive effect on these disparities (125), their persistence in the face of years of such intervention suggests that novel and systematic approaches are required. More information on contributors to such disparities will be necessary to inform the design of meaningful interventions to further improve vaccination among adult populations.

Source of original article: Centers for Disease Control and Prevention (CDC) / Morbidity and Mortality Weekly Report (MMWR) (
The content of this article does not necessarily reflect the views or opinion of Global Diaspora News (

To submit your press release: (

To advertise on Global Diaspora News: (

Sign up to Global Diaspora News newsletter ( to start receiving updates and opportunities directly in your email inbox for free.